Law No. 2016-012/ of May 6, 2016, relating to electronic transactions, exchanges, and services, establishes a safe harbour regime for intermediaries beyond copyright infringements. According to Art. 78 of the Law, when offering a service that involves transmitting information via a communication network or facilitating access to it, the service provider bears no responsibility for the transmitted data. This exemption applies as long as the provider meets specific criteria: they are not the source of the transmission, do not choose the recipient of the information, and do not select or modify the content being transmitted. The transmission and access provision activities referred to in the first paragraph of this article include the automatic, intermediate and transient storage of the information transmitted, provided that this storage is used exclusively for the execution of the transmission on the communication network and that its duration does not exceed the time reasonably necessary for the transmission.

The operators of telecommunications networks open to the public and telecommunications/ICT service providers are required at the time of subscription to proceed with the identification of subscribers under (Art. 9) of Ordinance No. 11-023/P-RM of 28 September 2011 relating to telecommunications and information and communication technologies.

Several cases of web content blocking have been reported in Mali. These include:
- Following a demonstration in 2016, it was reported that access to social networks (Twitter and Facebook) was interrupted. Viber and WhatsApp also experienced disruptions;
- Social media was reportedly shut down in June 2018 following demonstrations;
- In July 2018, during the presidential elections, it was reported that social networks were inaccessible. A WhatsApp and Twitter block was reported, along with two circumvention tool sites (guardianproject.info and anonymizer.ru);
- Social media and messaging were partially blocked for five days in July 2020 amid protests. Social networking platforms Twitter and Facebook, as well as messaging apps WhatsApp and Messenger, were restricted by Mali's leading private operator, Orange Mali. The cellular network of national telecom operator Malitel also restricted Instagram. Filtering was also comprehensive, with indications of near-total impact. The Internet measures were implemented at the ISP level, with each company applying them differently;
- The French broadcasters RFI and France 24 were definitively banned in April 2022.

The indicator "6.2.4 - Government Internet shut down in practice" of the V-Dem Dataset, which measures whether the government has the technical capacity to actively make internet service cease, thus interrupting domestic access to the internet or whether the government has decided to do so, has a score of 2 in Mali for the year 2023. This corresponds to "The government shut down domestic access to the Internet several times this year."

It is reported that the Malian Authority for the Regulation of Telecommunications and Posts (AMRTP), the executive authority for the supervision and administration of services in the telecommunications sector, is independent from the government in the decision-making process.

According to Art. 76 of Decree No. 2015-604/P-RM, a preference shall be given to the tender submitted by a community company. A community company is defined as a company whose head office is located in a member state of the West African Economic and Monetary Union (WAEMU). This preference must be quantified in the form of a percentage of the bid amount up to 15%. The terms and conditions of the application of community preference, particularly with regard to the types of acquisition concerned and their beneficiaries, are determined by the WAEMU Commission.

Art. 5.2 of Decree No. 2018-0473/PM-RM provides that in the case of a contract awarded by a decentralised authority or one of its public establishments, a contract applicant who plans to subcontract at least 30% of the overall value of the contract to a Malian company, a Malian artisan or a Malian artisanal company, may benefit from a margin of preference not exceeding 5%, which may be added to the Community's right of preference under public procurement regulations. Also, the Decree states that the contracting authorities must ensure that a proportion of public contracts are subject to competition between Small and Medium-sized Enterprises (Art. 5.4). On the other hand, according to Art. 11.1, a margin of preference of 25% is granted to products of Malian origin and/or to companies under Malian law whose capital is majority-owned by nationals for all types of contracts whose amounts do not reach the thresholds of public procurement. Furthermore, according to Art. 11.3, without prejudice to the provisions relating to national preference, when awarding a public contract or a public service delegation, a preference of 5% is given to the bid submitted by a craftsman or craft company with a fixed base or permanent establishment in Mali. This artisanal preference rate is cumulative, with a national preference rate of 15%, as referred to in Art. 11.1.

Mali is not a party to the World Trade Organization (WTO) Agreement on Government Procurement (GPA), nor does it have observer status.

Art. 6 of Law No. 2012-016 provides that foreign investors receive the same treatment as investors of Malian nationality subject to provisions contrary to the laws or treaties and agreements concluded by the Republic of Mali with the States of which they are nationals. They may freely any share of equity of the company they plan to create, subject to the provisions applicable to the sectors of activity which are subject to specific regulations.

According to the Bangui Agreement, ratified by 17 French-speaking States, including Mali, applicants resident outside the territory of the Member States must file through an agent selected in one of those Member States (Section III, Art. 8). The professional status of agent accredited to the African Intellectual Property Organization (OAPI) is governed by the Regulations on the profession of Authorised Agent before the OAPI.

Mali is a party to the Patent Cooperation Treaty (PCT).

The Revised Bangui Agreement is a regional intellectual property law that is not only a regional convention applicable in all member states but also serves as a national intellectual property law in Mali and each of the other member states. The Revised Bangui Agreement contains provisions on copyright in Annex VII: Chapter IV (Limitations to Economic Rights) and establishes a regime of copyright exceptions. However, the exceptions do not follow the fair use or fair dealing model, therefore limiting the lawful use of copyrighted work by others. In addition, Chapter IV of Title I of Law No. 2017-012 also provides for limitations on copyrights.

Mali has ratified the World Intellectual Property Organization (WIPO) Copyright Treaty.

Mali has ratified the World Intellectual Property Organization (WIPO) Performances and Phonograms Treaty.

Mali does not have comprehensive trade secret legislation. Yet, there are provisions addressing disclosure, acquisition or use of confidential information in the course of industrial or commercial activities by third parties in Art. 6 of Annex VIII of the Bangui Agreement ratified by 17 French-speaking States, including Mali, since 2002.