According to the Bangui Agreement, ratified by 17 States, including Guinea-Bissau, applicants resident outside the territory of the Member States must file through an agent selected in one of those Member States (Section III, Art. 8). The professional status of agent accredited to the African Intellectual Property Organization (OAPI) is governed by the Regulations on the Profession of Authorised Agent before the OAPI.

Guinea-Bissau is a party to the Patent Cooperation Treaty (PCT).

Guinea-Bissau has a copyright regime under the Copyright Code. However, the exceptions do not follow the fair use or fair dealing model, therefore limiting the lawful use of copyrighted work by others. Arts. 181-188 list the exceptions, which include: reproduction by organs of the press of speeches and other statements made in public; the performance of hymns or officially adopted patriotic songs; works of a religious nature during religious services or acts; work included in educational programs or books, when integrated into teaching; among others.
In addition, the Revised Bangui Agreement, which is a regional intellectual property law that is not only a regional convention applicable in all member states but also serves as a national intellectual property law in Guinea-Bissau and each of the other member states, contains provisions on copyright in Annex VII: Chapter IV (Limitations to Economic Rights) and establishes a regime of copyright exceptions. Nevertheless, these exceptions similarly do not conform to the fair use or fair dealing models.

Guinea-Bissau has not signed the World Intellectual Property Organization (WIPO) Copyright Treaty.

Guinea-Bissau is not a signatory of the 1996 World Trade Organization (WTO) Information Technology Agreement (ITA I) nor the 2015 expansion (ITA II).

According to Art. 66 of Decree-Law No. 20/2012, there is a community preference. When a public contract or delegation of public service is awarded, preference must be given to the bid submitted by a community company from the West African Economic Monetary Union - WAEMU community. The Community preference must be quantified in the form of a percentage of the bid amount of the offer. This percentage is set at 15%, and the Community preference margin must be provided in the tender document. In addition, according to Art. 30, in case of a contract with a local authority or one of the public entities, a candidate intending to subcontract at least 30% of the total contract value to a company from a national company may benefit from an additional preference margin up to 5%.

Guinea-Bissau is not a party to the World Trade Organization (WTO) Agreement on Government Procurement (GPA), nor does it have observer status.

It has been reported that eligibility to register a '.com.gn' domain name is restricted exclusively to companies based in Guinea.

According to Art. 7 of Decree No. D/2021/0196/PRG/CNRD/SGG, the practice of e-commerce is subject to a list of requirements, including having a dedicated domain name with a ".gn" or ".com" extension for the activity.

Guinea lacks a comprehensive framework for consumer protection that applies to online transactions.

Guinea has not signed the United Nations (UN) Convention on the Use of Electronic Communications in International Contracts.

Guinea has not adopted national legislation based on or influenced by the United Nations Commission on International Trade Law (UNCITRAL) Model Law on Electronic Commerce.

Guinea has not adopted national legislation based on or influenced by the United Nations Commission on International Trade Law (UNCITRAL) Model Law on Electronic Signatures.